WELCOMEWelcome to Zhu Lab

We are the Laboratory for Mass Spectrometry and Metabolomics, affiliated with Interdisciplinary Research Center on Biology and Chemistry (IRCBC), Shanghai Institute of Organic Chemistry (SIOC), Chinese Academy of Sciences (CAS).
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Research
Metabolites, the chemical entities that are transformed during metabolism, provide a functional readout of cellular biochemistry. With mass spectrometry based metabolomics technique, thousands of metabolites can now be quantitatively measured from minimal amounts of biological material, which…
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Software
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MetDNA

Large-scale metabolite annotation is a challenge in liquid chromatogram-mass spectrometry (LC-MS)-based untargeted metabolomics.
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AllCCS

The metabolome includes not just known but also unknown metabolites; however, metabolite annotation remains the bottleneck in untargeted metabolomics. Ion mobility – mass spectrometry (IM-MS) has emerged as a promising technology by providing multi-dimensional characterizations of metabolites
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Publications
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Deep-coverage single-cell metabolomics enabled by ion mobility-resolved mass cytometry

M. Luo, Y. Yin, Z. Zhou, H. Zhang, X. Chen, H. Wang, and Z.-J. Zhu*

Nature Methods, 2026, 23, 585-595.
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Quantitative profiling of lipid transport between organelles enabled by subcellular photocatalytic labeling

X. Chen†, R. He†, H. Xiong, R. Wang, Y. Yin, Y. Chen*, and Z.-J. Zhu*

Nature Chemistry, 2025, 17, 1534 - 1545.
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Metabolite Annotation from Knowns to Unknowns through Knowledge-guided Multi-layer Metabolic Networking

Z. Zhou†, M. Luo†, H. Zhang, Y. Yin, Y. Cai, and Z.-J. Zhu*

Nature Communications, 2022, 13: 6656.
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